Activity Assay:Article Title: Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya
Article Snippet: Liang et al. evaluated the antibacterial activity of neosartin B ( 44 ), 1,2,3,4-tetrahydro-2-methyl-1,3,4-trioxopyrazino [1,2- a ]indole ( 45 ), 1,2,3,4-tetrahydro-2,3-dimethyl-1,4-dioxopyrazino [1,2- a ]indole ( 46 ), 1,2,3,4-tetrahydro-2-methyl-1,3,4-trioxopyrazino (1,2- a ]indole ( 47 ), gliotoxin ( 49 ), acetylgliotoxin ( 50 ), bis(dethio)bis(methylthio)gliotoxin ( 51 ), reduced gliotoxin ( 52 ), 6-acetyl bis(methylthio)gliotoxin ( 53 ), didehydrobisdethiobis(methylthio)gliotoxin ( 54 ), and bis- N -norgliovictin ( 55 ) , isolated from a culture extract of the sea star-derived N. pseudofischeri , against three multidrug-resistant bacteria, i.e., the Gram-positive Staphylococcus aureus (ATCC 29213), the methicillin-resistant S. aureus (R3708), and the Gram-negative Escherichia coli (ATCC 25922), using a broth dilution method. .. However, only 49 and 52 exhibited significant inhibitory activity against these three bacteria with IC 50 values of 12.20, 1.53, 24.53 μM, and 48.78, 1.52, 97.56 μM, respectively, against S. aureus (ATCC 29213), MRSA S. aureus (R3708), and E. coli (ATCC 25922). ..
Bacteria:Article Title: Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya
Article Snippet: Liang et al. evaluated the antibacterial activity of neosartin B ( 44 ), 1,2,3,4-tetrahydro-2-methyl-1,3,4-trioxopyrazino [1,2- a ]indole ( 45 ), 1,2,3,4-tetrahydro-2,3-dimethyl-1,4-dioxopyrazino [1,2- a ]indole ( 46 ), 1,2,3,4-tetrahydro-2-methyl-1,3,4-trioxopyrazino (1,2- a ]indole ( 47 ), gliotoxin ( 49 ), acetylgliotoxin ( 50 ), bis(dethio)bis(methylthio)gliotoxin ( 51 ), reduced gliotoxin ( 52 ), 6-acetyl bis(methylthio)gliotoxin ( 53 ), didehydrobisdethiobis(methylthio)gliotoxin ( 54 ), and bis- N -norgliovictin ( 55 ) , isolated from a culture extract of the sea star-derived N. pseudofischeri , against three multidrug-resistant bacteria, i.e., the Gram-positive Staphylococcus aureus (ATCC 29213), the methicillin-resistant S. aureus (R3708), and the Gram-negative Escherichia coli (ATCC 25922), using a broth dilution method. .. However, only 49 and 52 exhibited significant inhibitory activity against these three bacteria with IC 50 values of 12.20, 1.53, 24.53 μM, and 48.78, 1.52, 97.56 μM, respectively, against S. aureus (ATCC 29213), MRSA S. aureus (R3708), and E. coli (ATCC 25922). ..
other:
Multiple Displacement Amplification:Article Title: Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
Article Snippet: .. The following are available online at https://www.mdpi.com/article/10.3390/ph14101035/s1 , Table S1: Viability of non-treated cells from IC 50 experiments at extracellular pH values of 7.4 and 6.5, Table S2: IC 50 values of free DXR and free CDDP given in combination on MDA-MB-231 and (the ‘doxorubicin resistant’) DXR-Res-231 cell lines, Table S3: Combination index (CI) of free DXR and free CDDP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S4: IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Table S5: Combination index (CI) of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S6: IC 50 values and combination index values of DXR and of CDDP delivered, in combination, by non-responsive-NP on MDA-MB-231 cell line, Figure S1: Release kinetics of responsive- and non-responsive DXR- and CDDP- NP at pH 7.4 and 6.5, Figure S2: K D of trastuzumab binding to the HER2 receptors on MDA-MB-231 and DXR-Res-231 cell lines, Figure S3: Individual free agent IC 50 values of DXR and of CDDP on MDA-MB-231 and DXR-Res-231 at pH 7.4 and 6.5, Figure S4: Flow Cytometry Demonstrating Relative HER2-Receptor Expression by Cells, Figure S5: IC 50 plots of responsive and non-responsive NP on the MDA-MB-231 (ATCC) cell line, Figure S6: IC 50 plots of responsive (black symbols) and non-responsive (white symbols) NP on the (‘doxorubicin-resistant’) DXR-Res-231 cell line, Figure S7: IC 50 measurements of responsive-NP not containing any of the chemotherapeutic agents, Figure S8: Normalized IC 50 values of free DXR and free CDDP introduced alone and in combination on MDA-MB-231 and DXR-Res-231 cell lines, Figure S9: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Figure S10: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive- and non-responsive-NP on the MDA-MB-231 cell line, Figure S11: Measured extracellular pH of spheroids formed by MDA-MB-231 and DXR-Res-231, Figure S12: Spatiotemporal microdistributions of the fluorescent drug surrogate CFDA-SE on MDA-MB-231 spheroids delivered by responsive-NP, designed for CDDP and for DXR, and of non-responsive NP, Figure S13: Spatiotemporal microdistributions of the free fluorophore CFDA-SE, used as surrogate of the free chemotherapeutic agents, on MDA-MB-231 spheroids. ..
Binding Assay:Article Title: Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
Article Snippet: .. The following are available online at https://www.mdpi.com/article/10.3390/ph14101035/s1 , Table S1: Viability of non-treated cells from IC 50 experiments at extracellular pH values of 7.4 and 6.5, Table S2: IC 50 values of free DXR and free CDDP given in combination on MDA-MB-231 and (the ‘doxorubicin resistant’) DXR-Res-231 cell lines, Table S3: Combination index (CI) of free DXR and free CDDP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S4: IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Table S5: Combination index (CI) of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S6: IC 50 values and combination index values of DXR and of CDDP delivered, in combination, by non-responsive-NP on MDA-MB-231 cell line, Figure S1: Release kinetics of responsive- and non-responsive DXR- and CDDP- NP at pH 7.4 and 6.5, Figure S2: K D of trastuzumab binding to the HER2 receptors on MDA-MB-231 and DXR-Res-231 cell lines, Figure S3: Individual free agent IC 50 values of DXR and of CDDP on MDA-MB-231 and DXR-Res-231 at pH 7.4 and 6.5, Figure S4: Flow Cytometry Demonstrating Relative HER2-Receptor Expression by Cells, Figure S5: IC 50 plots of responsive and non-responsive NP on the MDA-MB-231 (ATCC) cell line, Figure S6: IC 50 plots of responsive (black symbols) and non-responsive (white symbols) NP on the (‘doxorubicin-resistant’) DXR-Res-231 cell line, Figure S7: IC 50 measurements of responsive-NP not containing any of the chemotherapeutic agents, Figure S8: Normalized IC 50 values of free DXR and free CDDP introduced alone and in combination on MDA-MB-231 and DXR-Res-231 cell lines, Figure S9: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Figure S10: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive- and non-responsive-NP on the MDA-MB-231 cell line, Figure S11: Measured extracellular pH of spheroids formed by MDA-MB-231 and DXR-Res-231, Figure S12: Spatiotemporal microdistributions of the fluorescent drug surrogate CFDA-SE on MDA-MB-231 spheroids delivered by responsive-NP, designed for CDDP and for DXR, and of non-responsive NP, Figure S13: Spatiotemporal microdistributions of the free fluorophore CFDA-SE, used as surrogate of the free chemotherapeutic agents, on MDA-MB-231 spheroids. ..
Flow Cytometry:Article Title: Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
Article Snippet: .. The following are available online at https://www.mdpi.com/article/10.3390/ph14101035/s1 , Table S1: Viability of non-treated cells from IC 50 experiments at extracellular pH values of 7.4 and 6.5, Table S2: IC 50 values of free DXR and free CDDP given in combination on MDA-MB-231 and (the ‘doxorubicin resistant’) DXR-Res-231 cell lines, Table S3: Combination index (CI) of free DXR and free CDDP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S4: IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Table S5: Combination index (CI) of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S6: IC 50 values and combination index values of DXR and of CDDP delivered, in combination, by non-responsive-NP on MDA-MB-231 cell line, Figure S1: Release kinetics of responsive- and non-responsive DXR- and CDDP- NP at pH 7.4 and 6.5, Figure S2: K D of trastuzumab binding to the HER2 receptors on MDA-MB-231 and DXR-Res-231 cell lines, Figure S3: Individual free agent IC 50 values of DXR and of CDDP on MDA-MB-231 and DXR-Res-231 at pH 7.4 and 6.5, Figure S4: Flow Cytometry Demonstrating Relative HER2-Receptor Expression by Cells, Figure S5: IC 50 plots of responsive and non-responsive NP on the MDA-MB-231 (ATCC) cell line, Figure S6: IC 50 plots of responsive (black symbols) and non-responsive (white symbols) NP on the (‘doxorubicin-resistant’) DXR-Res-231 cell line, Figure S7: IC 50 measurements of responsive-NP not containing any of the chemotherapeutic agents, Figure S8: Normalized IC 50 values of free DXR and free CDDP introduced alone and in combination on MDA-MB-231 and DXR-Res-231 cell lines, Figure S9: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Figure S10: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive- and non-responsive-NP on the MDA-MB-231 cell line, Figure S11: Measured extracellular pH of spheroids formed by MDA-MB-231 and DXR-Res-231, Figure S12: Spatiotemporal microdistributions of the fluorescent drug surrogate CFDA-SE on MDA-MB-231 spheroids delivered by responsive-NP, designed for CDDP and for DXR, and of non-responsive NP, Figure S13: Spatiotemporal microdistributions of the free fluorophore CFDA-SE, used as surrogate of the free chemotherapeutic agents, on MDA-MB-231 spheroids. ..
Expressing:Article Title: Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
Article Snippet: .. The following are available online at https://www.mdpi.com/article/10.3390/ph14101035/s1 , Table S1: Viability of non-treated cells from IC 50 experiments at extracellular pH values of 7.4 and 6.5, Table S2: IC 50 values of free DXR and free CDDP given in combination on MDA-MB-231 and (the ‘doxorubicin resistant’) DXR-Res-231 cell lines, Table S3: Combination index (CI) of free DXR and free CDDP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S4: IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Table S5: Combination index (CI) of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines at extracellular pH 7.4 and 6.5, Table S6: IC 50 values and combination index values of DXR and of CDDP delivered, in combination, by non-responsive-NP on MDA-MB-231 cell line, Figure S1: Release kinetics of responsive- and non-responsive DXR- and CDDP- NP at pH 7.4 and 6.5, Figure S2: K D of trastuzumab binding to the HER2 receptors on MDA-MB-231 and DXR-Res-231 cell lines, Figure S3: Individual free agent IC 50 values of DXR and of CDDP on MDA-MB-231 and DXR-Res-231 at pH 7.4 and 6.5, Figure S4: Flow Cytometry Demonstrating Relative HER2-Receptor Expression by Cells, Figure S5: IC 50 plots of responsive and non-responsive NP on the MDA-MB-231 (ATCC) cell line, Figure S6: IC 50 plots of responsive (black symbols) and non-responsive (white symbols) NP on the (‘doxorubicin-resistant’) DXR-Res-231 cell line, Figure S7: IC 50 measurements of responsive-NP not containing any of the chemotherapeutic agents, Figure S8: Normalized IC 50 values of free DXR and free CDDP introduced alone and in combination on MDA-MB-231 and DXR-Res-231 cell lines, Figure S9: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive-NP on MDA-MB-231 and DXR-Res-231 cell lines, Figure S10: Normalized IC 50 values of DXR and of CDDP delivered, in combination, by responsive- and non-responsive-NP on the MDA-MB-231 cell line, Figure S11: Measured extracellular pH of spheroids formed by MDA-MB-231 and DXR-Res-231, Figure S12: Spatiotemporal microdistributions of the fluorescent drug surrogate CFDA-SE on MDA-MB-231 spheroids delivered by responsive-NP, designed for CDDP and for DXR, and of non-responsive NP, Figure S13: Spatiotemporal microdistributions of the free fluorophore CFDA-SE, used as surrogate of the free chemotherapeutic agents, on MDA-MB-231 spheroids. ..
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